General Information
-
DRAMP ID
- DRAMP03344
-
Peptide Name
- Alpha-defensin cryptdin-17 (CRYP17; Rodents, mammals, animals)
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Source
- Mus musculus (Mouse)
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Family
- Belongs to the alpha-defensin family
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Gene
- Defa17
-
Sequence
- LRDLVCYCRKRGCKRREHMNGTCRKGHLLYTLCCR
-
Sequence Length
- 35
-
UniProt Entry
- Q64016
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Disulfide bonds between Cys6 and Cys34,Cys8 and Cys23,Cys13 and Cys33.
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Stereochemistry
- L
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03344.
Physicochemical Information
-
Formula
- C175H298N64O45S7
Absent Amino Acids
- AFIPQSW
Common Amino Acids
- R
Mass
- 4243.11
PI
- 9.77
Basic Residues
- 12
Acidic Residues
- 2
Hydrophobic Residues
- 6
Net Charge
- +10
-
Boman Index
- -116.51
Hydrophobicity
- -0.72
Aliphatic Index
- 64
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 3355
Absorbance 280nm
- 98.68
Polar Residues
- 14
DRAMP03344
Comments Information
Function
- Probably contributes to the antimicrobial barrier Function
Literature Information
- ·Literature 1
-
Title
- Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms.
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Pubmed ID
- 7927786
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Reference
- Genomics. 1994;19:448-453.
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Author
- Ouellette AJ, Hsieh MM, Nosek MT, Cano-Gauci DF, Huttner KM, Buick RN, Selsted ME.