General Information
-
DRAMP ID
- DRAMP03346
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Peptide Name
- Alpha-defensin cryptdin-21 (Defensin-related cryptdin-21; Rodents, mammals, animals)
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Source
- Mus musculus (Mouse)
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Family
- Belongs to the alpha-defensin family
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Gene
- Defa21
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Sequence
- SRDLICLCRNRRCNRGELFYGTCAGPFLRCCRRRR
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Sequence Length
- 35
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UniProt Entry
- Q8C1P2
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Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03346.
Physicochemical Information
-
Formula
- C173H291N67O45S6
Absent Amino Acids
- HKMQVW
Common Amino Acids
- R
Mass
- 4222
PI
- 10.58
Basic Residues
- 10
Acidic Residues
- 2
Hydrophobic Residues
- 8
Net Charge
- +8
-
Boman Index
- -141.25
Hydrophobicity
- -0.643
Aliphatic Index
- 58.57
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1865
Absorbance 280nm
- 54.85
Polar Residues
- 14
DRAMP03346
Comments Information
Function
- May have microbicidal activities (By similarity).
PTM
- Contains three disulfide bonds (By similarity).
Literature Information
- ·Literature 1
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Title
- Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes.
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Pubmed ID
- 15494476
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Reference
- Physiol Genomics. 2004 Dec 15;20(1):1-11.
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Author
- Patil A, Hughes AL, Zhang G.