General Information

    • DRAMP ID

    • DRAMP03348

    • Peptide Name

    • Alpha-defensin cryptdin-23 (Defensin-related cryptdin-23; Rodents, mammals, animals)

    • Source

    • Mus musculus (Mouse)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Defa23

    • Sequence

    • LRDLVCYCRTRGCKRRERMNGTCRKGHLIYTLCC

    • Sequence Length

    • 34

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03348 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03348.

Physicochemical Information

    • Formula

    • C167H286N60O45S7

    • Absent Amino Acids

    • AFPQSW

    • Common Amino Acids

    • R

    • Mass

    • 4078.9

    • PI

    • 9.61

    • Basic Residues

    • 10

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +8

    • Boman Index

    • -108.87

    • Hydrophobicity

    • -0.532

    • Aliphatic Index

    • 65.88

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 3355

    • Absorbance 280nm

    • 101.67

    • Polar Residues

    • 15

DRAMP03348

DRAMP03348 chydropathy plot

Comments Information

    • Function

    • May have microbicidal activities (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes.

    • Reference

    • Physiol Genomics. 2004 Dec 15;20(1):1-11.

    • Author

    • Patil A, Hughes AL, Zhang G.
  • ·Literature 2

    • Title

    • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

    • Reference

    • Genome Res. 2004 Oct;14(10B):2121-2127.

    • Author

    • The MGC Project Team.