General Information
-
DRAMP ID
- DRAMP03349
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Peptide Name
- Alpha-defensin cryptdin-24 (Defensin-related cryptdin-24; Rodents, mammals, animals)
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Source
- Mus musculus (Mouse)
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Family
- Belongs to the alpha-defensin family
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Gene
- Defa24
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Sequence
- LRDLVCYCRARGCKGRERMNGTCSKGHLLYMLCC
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Sequence Length
- 34
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UniProt Entry
- Q5G865
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Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03349.
Physicochemical Information
-
Formula
- C160H270N54O44S8
Absent Amino Acids
- FIPQW
Common Amino Acids
- C
Mass
- 3910.72
PI
- 9.15
Basic Residues
- 8
Acidic Residues
- 2
Hydrophobic Residues
- 7
Net Charge
- +6
-
Boman Index
- -72.19
Hydrophobicity
- -0.174
Aliphatic Index
- 68.82
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 3355
Absorbance 280nm
- 101.67
Polar Residues
- 15
DRAMP03349
Comments Information
Function
- May have microbicidal activities (By similarity).
Literature Information
- ·Literature 1
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Title
- Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes.
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Pubmed ID
- 15494476
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Reference
- Physiol Genomics. 2004 Dec 15;20(1):1-11.
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Author
- Patil A, Hughes AL, Zhang G.