General Information

    • DRAMP ID

    • DRAMP03350

    • Peptide Name

    • Alpha-defensin cryptdin-25 (Defensin-related cryptdin-25; Rodents, mammals, animals)

    • Source

    • Mus musculus (Mouse)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Defa25

    • Sequence

    • CEDLICYCRTRGCKRRERLNGTCRKGHLMYMLWCC

    • Sequence Length

    • 35

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03350 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03350.

Physicochemical Information

    • Formula

    • C176H289N59O47S9

    • Absent Amino Acids

    • AFPQSV

    • Common Amino Acids

    • C

    • Mass

    • 4272.14

    • PI

    • 9.03

    • Basic Residues

    • 9

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +6

    • Boman Index

    • -96.27

    • Hydrophobicity

    • -0.489

    • Aliphatic Index

    • 55.71

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 8855

    • Absorbance 280nm

    • 260.44

    • Polar Residues

    • 15

DRAMP03350

DRAMP03350 chydropathy plot

Comments Information

    • Function

    • May have microbicidal activities (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes.

    • Reference

    • Physiol Genomics. 2004 Dec 15;20(1):1-11.

    • Author

    • Patil A, Hughes AL, Zhang G.