General Information

    • DRAMP ID

    • DRAMP03353

    • Peptide Name

    • Alpha-defensin-related sequence 2 (Defensin-related cryptdin 2; Rodents, mammals, animals)

    • Source

    • Mus musculus (Mouse)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Defa-rs2

    • Sequence

    • LGWGRRCPQCPRCPSCPSCPRCPRCPRCKCNPK

    • Sequence Length

    • 33

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03353 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03353.

Physicochemical Information

    • Formula

    • C151H250N56O38S9

    • Absent Amino Acids

    • ADEFHIMTVY

    • Common Amino Acids

    • C

    • Mass

    • 3746.54

    • PI

    • 9.43

    • Basic Residues

    • 8

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +8

    • Boman Index

    • -98.95

    • Hydrophobicity

    • -0.958

    • Aliphatic Index

    • 11.82

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 6000

    • Absorbance 280nm

    • 187.5

    • Polar Residues

    • 14

DRAMP03353

DRAMP03353 chydropathy plot

Comments Information

    • Function

    • Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activit.

    • Developmental stage

    • Accumulates to high levels in intestinal crypt epithelium during postnatal development.

    • Tissue specificity

    • Small bowel, spleen, colon, kidney, liver, stomach and femur marrow.

Literature Information

  • ·Literature 1

    • Title

    • A novel mouse gene family coding for cationic, cysteine-richpeptides. Regulation in small intestine and cells of myeloid origin.

    • Reference

    • J. Biol. Chem. 1990;265:9831-9837.

    • Author

    • Ouellette A.J, Lauldi J.C.
  • ·Literature 2

    • Title

    • A novel gene family coding for cationic, cysteine-rich peptides. Regulation in mouse small intestine and cells of myeloid origin.

    • Reference

    • J Biol Chem. 1994 Jul 15;269(28):18702.

    • Author

  • ·Literature 3

    • Title

    • A family of defensin-like genes codes for diverse cysteine-rich peptides in mouse Paneth cells.

    • Reference

    • Genomics 1994;24:99-109.

    • Author