General Information
-
DRAMP ID
- DRAMP03354
-
Peptide Name
- Alpha-defensin-related sequence 7 (Defensin-related cryptdin 3; Rodents, mammals, animals)
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Source
- Mus musculus (Mouse)
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Family
- Belongs to the alpha-defensin family
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Gene
- Defa-rs7
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Sequence
- PRCPPCPRCSWCPRCPTCPRCNCNPK
-
Sequence Length
- 26
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03354.
Physicochemical Information
-
Formula
- C120H192N42O31S8
Absent Amino Acids
- ADEFGHILMQVY
Common Amino Acids
- CP
Mass
- 2975.59
PI
- 9.02
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 1
Net Charge
- +5
-
Boman Index
- -71.91
Hydrophobicity
- -0.927
Aliphatic Index
- 0
Half Life
-
- Mammalian:>20 hour
- Yeast:>20 hour
- E.coli:?
Extinction Coefficient Cystines
- 6000
Absorbance 280nm
- 240
Polar Residues
- 12
DRAMP03354
Comments Information
Function
- Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activit.
Tissue specificity
- Paneth cells of the small bowel.
Literature Information
- ·Literature 1
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Title
- A family of defensin-like genes codes for diverse cysteine-rich peptides in mouse Paneth cells.
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Pubmed ID
- 7896294
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Reference
- Genomics. 1994 Nov 1;24(1):99-109.
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Author
- Huttner K.M, Ouellette A.J.
- ·Literature 2
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Title
- Increased diversity of intestinal antimicrobial peptides by covalentdimer formation.
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Pubmed ID
- 15235601
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Reference
- Nat. Immunol. 2004;5:836-843.
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Author
- Hornef M.W, Putsep K, Karlsson J, Refai E, Andersson M.