General Information

    • DRAMP ID

    • DRAMP03356

    • Peptide Name

    • Alpha-defensin-related sequence 12 (Defensin-related cryptdin 12; Rodents, mammals, animals)

    • Source

    • Mus musculus (Mouse)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Defa-rs12

    • Sequence

    • PPCPSCLSCPWCPRCLRCPMCKCNPK

    • Sequence Length

    • 26

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03356 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03356.

Physicochemical Information

    • Formula

    • C121H196N36O30S9

    • Absent Amino Acids

    • ADEFGHIQTVY

    • Common Amino Acids

    • C

    • Mass

    • 2923.65

    • PI

    • 8.81

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +4

    • Boman Index

    • -29.62

    • Hydrophobicity

    • -0.173

    • Aliphatic Index

    • 30

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 6000

    • Absorbance 280nm

    • 240

    • Polar Residues

    • 11

DRAMP03356

DRAMP03356 chydropathy plot

Comments Information

    • Function

    • Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activities.

    • Tissue specificity

    • Paneth cells of the small bowel.

Literature Information

  • ·Literature 1

    • Title

    • A family of defensin-like genes codes for diverse cysteine-rich peptides in mouse Paneth cells.

    • Reference

    • Genomics. 1994 Nov 1;24(1):99-109.

    • Author

    • Huttner KM, Ouellette AJ.