General Information

    • DRAMP ID

    • DRAMP03364

    • Peptide Name

    • Hepcidin (mammals, rodents, animals)

    • Source

    • Mus musculus (Mouse)

    • Family

    • Not found

    • Gene

    • Hamp

    • Sequence

    • DTNFPICIFCCKCCNNSQCGICCKT

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03364 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03364.

Physicochemical Information

    • Formula

    • C111H177N31O35S8

    • Absent Amino Acids

    • AEHLMRVWY

    • Common Amino Acids

    • C

    • Mass

    • 2762.29

    • PI

    • 7.7

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +1

    • Boman Index

    • -21.92

    • Hydrophobicity

    • 0.384

    • Aliphatic Index

    • 46.8

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 500

    • Absorbance 280nm

    • 20.83

    • Polar Residues

    • 15

DRAMP03364

DRAMP03364 chydropathy plot

Comments Information

    • Function

    • Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity.

    • Tissue specificity

    • Highly expressed in the liver and to a much lesser extent in the heart.

    • PTM

    • Contains four disulfide bonds 7-23; 10-13; 11-19; 14-22.

Literature Information

  • ·Literature 1

    • Title

    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload.

    • Reference

    • J Biol Chem. 2001 Mar 16;276(11):7811-7819.

    • Author

    • Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loréal O.
  • ·Literature 2

    • Title

    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice.

    • Reference

    • Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8780-8785.

    • Author

    • Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S.