General Information

    • DRAMP ID

    • DRAMP03365

    • Peptide Name

    • Hepcidin-2 (mammals, rodents, animals)

    • Source

    • Mus musculus (Mouse)

    • Family

    • Not found

    • Gene

    • Hamp2

    • Sequence

    • DINFPICRFCCQCCNKPSCGICCEE

    • Sequence Length

    • 25

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03365 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03365.

Physicochemical Information

    • Formula

    • C114H178N32O36S8

    • Absent Amino Acids

    • AHLMTVWY

    • Common Amino Acids

    • C

    • Mass

    • 2829.34

    • PI

    • 4.68

    • Basic Residues

    • 2

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 5

    • Net Charge

    • -1

    • Boman Index

    • -33.13

    • Hydrophobicity

    • 0.212

    • Aliphatic Index

    • 46.8

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 500

    • Absorbance 280nm

    • 20.83

    • Polar Residues

    • 12

DRAMP03365

DRAMP03365 chydropathy plot

Comments Information

    • Function

    • Seems to act as a signaling molecule involved in the maintenance of iron homeostasis.

    • Tissue specificity

    • Highly expressed in the liver and to a much lesser extent in the heart. Also expressed in pancreas.

    • PTM

    • Contains four disulfide bonds 7-23; 10-13; 11-19; 14-22.

Literature Information

  • ·Literature 1

    • Title

    • Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload.

    • Reference

    • FEBS Lett. 2003 May 8;542(1-3):22-26.

    • Author

    • Ilyin G, Courselaud B, Troadec MB, Pigeon C, Alizadeh M, Leroyer P, Brissot P, Loréal O.
  • ·Literature 2

    • Title

    • The transcriptional landscape of the mammalian genome.

    • Reference

    • Science. 2005 Sep 2;309(5740):1559-1563.

    • Author

    • Carninci P, Kasukawa T, Katayama S, et al.