• DRAMP ID

    • DRAMP03367
    • Peptide Name

    • Beta-defensin 2 (BD-2, mBD-2; Defensin, beta 2; Defb2; Rodents, mammals, animals)
    • Source

    • Mus musculus (Mouse)
    • Family

    • Belongs to the beta-defensin family
    • Gene

    • Defb2
    • Sequence

    • AVGSLKSIGYEAELDHCHTNGGYCVRAICPPSARRPGSCFPEKNPCCKYMK
    • Sequence Length

    • 51
    • Protein Existence

    • Transcript level
    • Biological Activity

    • Antimicrobial, Antibacterial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03367 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP03367.
    • Formula

    • C237H372N70O70S7
    • Absent Amino Acids

    • QW
    • Common Amino Acids

    • CGP
    • Mass

    • 5546.41
    • PI

    • 8.63
    • Basic Residues

    • 9
    • Acidic Residues

    • 4
    • Hydrophobic Residues

    • 11
    • Net Charge

    • +5
    • Boman Index

    • -82.59
    • Hydrophobicity

    • -0.439
    • Aliphatic Index

    • 49.8
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 4845
    • Absorbance 280nm

    • 96.9
    • Polar Residues

    • 21

DRAMP03367

DRAMP03367 chydropathy plot
    • PTM

    • Contains three disulfide bonds 17-46; 24-39; 29-47.
    • Tissue specificity

    • Kidney, uterus and to a lesser extent in heart.
    • Induction

    • In tracheal epithelium, by lipopolysaccharide or inflammation.
  • ·Literature 1
    • Title

    • A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide.
    • Reference

    • FEBS Lett. 1999 Jan 8;442(1):112-116.
    • Author

    • Morrison GM, Davidson DJ, Dorin JR.