• DRAMP ID

    • DRAMP03369
    • Peptide Name

    • Beta-defensin 4 (BD-4, mBD-4; Defensin, beta 4; Rodents, mammals, animals)
    • Source

    • Mus musculus (Mouse)
    • Family

    • Belongs to the beta-defensin family
    • Gene

    • Defb4
    • Sequence

    • QIINNPITCMTNGAICWGPCPTAFRQIGNCGHFKVRCCKIR
    • Sequence Length

    • 41
    • Protein Existence

    • Transcript level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-negative bacterium: Escherichia coli;
      • Gram-positive bacterium: Staphylococcus aureus.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys9 and Cys37,Cys16 and Cys30,Cys20 and Cys38.
    • Stereochemistry

    • L
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03369 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP03369.
    • Formula

    • C196H315N61O51S7
    • Absent Amino Acids

    • DELSY
    • Common Amino Acids

    • CI
    • Mass

    • 4566.46
    • PI

    • 9.22
    • Basic Residues

    • 6
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 12
    • Net Charge

    • +6
    • Boman Index

    • -46.61
    • Hydrophobicity

    • 0.059
    • Aliphatic Index

    • 69.02
    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5875
    • Absorbance 280nm

    • 146.88
    • Polar Residues

    • 17

DRAMP03369

DRAMP03369 chydropathy plot
    • PTM

    • Contains three disulfide bonds 9-37; 16-30; 20-38. When expressed as a fusion protein, mBD-4 showed activity against both E. coli and S. aureus at 1ug/ml as well as chemotactic activity via CCR6-expressing cells (Rohrl J et al. J Biol Chem. 2010 Mar 5;285(10)
  • ·Literature 1
    • Title

    • A novel murine beta-defensin expressed in tongue, esophagus, and trachea.
    • Reference

    • J Biol Chem. 2000 Oct 27;275(43):33314-33320.
    • Author

    • Jia HP, Wowk SA, Schutte BC, Lee SK, Vivado A, Tack BF, Bevins CL, McCray PB Jr.