General Information
-
DRAMP ID
- DRAMP03370
-
Peptide Name
- Beta-defensin 6 (BD-6, mBD-6; Defensin, beta 6; Rodents, mammals, animals)
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Source
- Mus musculus (Mouse)
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Family
- Belongs to the beta-defensin family
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Gene
- Defb6
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Sequence
- QLINSPVTCMSYGGSCQRSCNGGFRLGGHCGHPKIRCCRRK
-
Sequence Length
- 41
-
UniProt Entry
- Q91VD6
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Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
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Target Organism
-
- Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=20 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
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N-terminal Modification
- Free
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C-terminal Modification
- Free
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Nonterminal Modifications and Unusual Amino Acids
- Disulfide bonds between Cys9 and Cys37,Cys16 and Cys30,Cys20 and Cys38.
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Stereochemistry
- L
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Structure
- Bridge
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP03370_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C182H300N66O52S7
Absent Amino Acids
- ADEW
Common Amino Acids
- G
Mass
- 4469.21
PI
- 9.69
Basic Residues
- 9
Acidic Residues
- 0
Hydrophobic Residues
- 6
Net Charge
- +9
-
Boman Index
- -92.38
Hydrophobicity
- -0.522
Aliphatic Index
- 45.12
Half Life
-
- Mammalian:0.8 hour
- Yeast:10 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1865
Absorbance 280nm
- 46.63
Polar Residues
- 21
DRAMP03370
Comments Information
PTM
- Contains three disulfide bonds 9-37; 16-30; 20-38.
Predominantly expressed in skeletal muscle, also expressed in esophagus, tongue, and trachea. Also expressed in lung when induced by lipopolysaccharide. Expressed constitutively and induced by lipopolysaccharide (LPS).
Literature Information
- ·Literature 1
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Title
- A novel mouse beta-defensin, mBD-6, predominantly expressed in skeletal muscle.
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Pubmed ID
- 11408484
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Reference
- J Biol Chem. 2001 Aug 24;276(34):31510-31514.
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Author
- Yamaguchi Y, Fukuhara S, Nagase T, Tomita T, Hitomi S, Kimura S, Kurihara H, Ouchi Y.