• DRAMP ID

    • DRAMP03372
    • Peptide Name

    • Beta-defensin 7 (BD-7, mBD-7; Defensin, beta 7; Rodents, mammals, animals)
    • Source

    • Mus musculus (Mouse)
    • Family

    • Belongs to the beta-defensin family
    • Gene

    • Defb7
    • Sequence

    • NSKRACYREGGECLQRCIGLFHKIGTCNFRFKCCKFQIPEKKTKIL
    • Sequence Length

    • 46
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Combine helix and strand structure
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03372 helical wheel diagram
    • PDB ID

    • 1E4T resolved by NMR.
  • 1E4T-> 
    • Predicted Structure

    • There is no predicted structure for DRAMP03372.
    • Formula

    • C237H385N71O61S6
    • Absent Amino Acids

    • DMVW
    • Common Amino Acids

    • K
    • Mass

    • 5397.46
    • PI

    • 9.59
    • Basic Residues

    • 12
    • Acidic Residues

    • 3
    • Hydrophobic Residues

    • 12
    • Net Charge

    • +9
    • Boman Index

    • -97.05
    • Hydrophobicity

    • -0.485
    • Aliphatic Index

    • 61.52
    • Half Life

      • Mammalian:1.4 hour
      • Yeast:3 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1865
    • Absorbance 280nm

    • 41.44
    • Polar Residues

    • 16

DRAMP03372

DRAMP03372 chydropathy plot
    • PTM

    • Contains three disulfide bonds 6-33; 13-27; 17-34.
  • ·Literature 1
    • Title

    • Cloning and characterization of mBD-7 and mBD-8, two novel mouse beta-defensins.
    • Reference

    • Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
    • Author

    • Conejo-Garcia JR, Nehls MC, Wattler S, Bals R, Heitland A, Kluever E, Liepke C, Adermann K, Forssmann WG.
  • ·Literature 2
    • Title

    • Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity.
    • Reference

    • Protein Sci. 2001 Dec;10(12):2470-2479.
    • Author

    • Bauer F, Schweimer K, Klüver E, Conejo-Garcia JR, Forssmann WG, Rösch P, Adermann K, Sticht H.