• DRAMP ID

    • DRAMP03378
    • Peptide Name

    • Beta-defensin 13 (BD-13, mBD-13; Defensin, beta 13; Rodents, mammals, animals)
    • Source

    • Mus musculus (Mouse)
    • Family

    • Belongs to the beta-defensin family
    • Gene

    • Defb13
    • Sequence

    • TLYRRFLCKKMNGQCEAECFTFEQKIGTCQANFLCCRKRKEH
    • Sequence Length

    • 42
    • Protein Existence

    • Transcript level
    • Biological Activity

    • Antimicrobial, Antibacterial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03378 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP03378.
    • Formula

    • C217H346N66O60S7
    • Absent Amino Acids

    • DPSVW
    • Common Amino Acids

    • C
    • Mass

    • 5063.96
    • PI

    • 9.1
    • Basic Residues

    • 10
    • Acidic Residues

    • 4
    • Hydrophobic Residues

    • 10
    • Net Charge

    • +6
    • Boman Index

    • -109.95
    • Hydrophobicity

    • -0.686
    • Aliphatic Index

    • 41.9
    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1865
    • Absorbance 280nm

    • 45.49
    • Polar Residues

    • 14

DRAMP03378

DRAMP03378 chydropathy plot
    • PTM

    • Contains three disulfide bonds 8-35; 15-29; 19-36.
    • Tissue specificity

    • Expressed in testis and to a lesser extent in epididymis (caput, corpus and cauda). Also weakly expressed in kidneys.
  • ·Literature 1
    • Title

    • Signal sequence conservation and mature peptide divergence within subgroups of the murine beta-defensin gene family.
    • Reference

    • Mol Biol Evol. 2003 Mar;20(3):460-470.
    • Author

    • Morrison G.M, Semple C.A.M, Kilanowski F.M, Hill R.E, Dorin J.R.
  • ·Literature 2
    • Title

    • Lineage-specific biology revealed by a finished genome assembly of the mouse.
    • Reference

    • PLoS Biol. 2009 May 5;7(5):e1000112.
    • Author

    • Church D.M, Goodstadt L, Hillier L.W, Zody M.C, Goldstein S. et al, Ponting C.P.
  • ·Literature 3
    • Title

    • Identification on mouse chromosome 8 of new beta-defensin genes with regionally specific expression in the male reproductive organ.
    • Reference

    • J Biol Chem. 2004 Mar 26;279(13):12421-6.
    • Author

    • Zaballos A, Villares R, Albar JP, Martínez-A C, Márquez G.