General Information

    • DRAMP ID

    • DRAMP03385

    • Peptide Name

    • Beta-defensin 25 (BD-25, mBD-25; Defensin, beta 25; Rodents, mammals, animals)

    • Source

    • Mus musculus (Mouse)

    • Family

    • Belongs to the beta-defensin family

    • Gene

    • Defb25

    • Sequence

    • EFKRCWNGQGACRTFCTRQETFMHLCPDASLCCLSYSFKPSRPSRVGDV

    • Sequence Length

    • 49

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03385 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03385.

Physicochemical Information

    • Formula

    • C241H370N72O70S7

    • Absent Amino Acids

    • I

    • Common Amino Acids

    • C

    • Mass

    • 5620.45

    • PI

    • 8.68

    • Basic Residues

    • 8

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +4

    • Boman Index

    • -110.43

    • Hydrophobicity

    • -0.425

    • Aliphatic Index

    • 39.8

    • Half Life

      • Mammalian:1 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 7365

    • Absorbance 280nm

    • 153.44

    • Polar Residues

    • 19

DRAMP03385

DRAMP03385 chydropathy plot

Comments Information

    • PTM

    • Contains three disulfide bonds 5-32; 12-26; 16-33.

Literature Information

  • ·Literature 1

    • Title

    • Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.

    • Reference

    • Physiol Genomics. 2005 Sep 21;23(1):5-17.

    • Author

    • Patil A.A, Cai Y, Sang Y, Blecha F, Zhang G.