General Information

    • DRAMP ID

    • DRAMP03389

    • Peptide Name

    • Beta-defensin 34 (BD-34, mBD-34; Defensin, beta 34; Rodents, mammals, animals)

    • Source

    • Mus musculus (House mouse)

    • Family

    • Belongs to the beta-defensin family

    • Gene

    • Defb34

    • Sequence

    • FFFFDEKCSRINGRCTASCLKNEELVALCWKNLKCCVTVQSCGRSKGNQSDEGSGHMGTRG

    • Sequence Length

    • 61

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03389 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03389.

Physicochemical Information

    • Formula

    • C282H449N87O89S8

    • Absent Amino Acids

    • PY

    • Common Amino Acids

    • CGS

    • Mass

    • 6738.68

    • PI

    • 8.57

    • Basic Residues

    • 10

    • Acidic Residues

    • 6

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +4

    • Boman Index

    • -130.04

    • Hydrophobicity

    • -0.439

    • Aliphatic Index

    • 49.51

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5875

    • Absorbance 280nm

    • 97.92

    • Polar Residues

    • 27

DRAMP03389

DRAMP03389 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activity.

    • Tissue specificity

    • Only expressed in epididymis (caput, corpus and cauda).

    • PTM

    • Contains three disulfide bonds (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Identification on mouse chromosome 8 of new beta-defensin genes with regionally specific expression in the male reproductive organ.

    • Reference

    • J Biol Chem. 2004 Mar 26;279(13):12421-6.

    • Author

    • Zaballos A, Villares R, Albar JP, Martínez-A C, Márquez G.