General Information
-
DRAMP ID
- DRAMP03390
-
Peptide Name
- Beta-defensin 35 (BD-35, mBD-35; Defensin, beta 35; Rodents, mammals, animals)
-
Source
- Mus musculus (Mouse)
-
Family
- Belongs to the beta-defensin family
-
Gene
- Defb35
-
Sequence
- EIAVCETCRLGRGKCRRACIESEKIVGWCKLNFFCCRERI
-
Sequence Length
- 40
-
UniProt Entry
- Q8R2I3
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Bridge
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03390.
Physicochemical Information
-
Formula
- C198H329N63O54S7
Absent Amino Acids
- DHMPQY
Common Amino Acids
- C
Mass
- 4680.6
PI
- 8.84
Basic Residues
- 9
Acidic Residues
- 5
Hydrophobic Residues
- 13
Net Charge
- +4
-
Boman Index
- -91.54
Hydrophobicity
- -0.065
Aliphatic Index
- 78
Half Life
-
- Mammalian:1 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5875
Absorbance 280nm
- 150.64
Polar Residues
- 13
DRAMP03390
Comments Information
PTM
- Contains three disulfide bonds 8-35; 15-29; 19-36.
Literature Information
- ·Literature 1
-
Title
- Signal sequence conservation and mature peptide divergence within subgroups of the murine beta-defensin gene family.
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Pubmed ID
- 12644567
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Reference
- J Biol Chem. 2004 Mar 26;279(13):12421-12426.
-
Author
- Morrison G.M, Semple C.A.M, Kilanowski F.M, Hill R.E, Dorin J.R.
- ·Literature 2
-
Title
- Identification on mouse chromosome 8 of new beta-defensin genes with regionally specific expression in the male reproductive organ.
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Pubmed ID
- 14718547
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Reference
- J Biol Chem. 2004 Mar 26;279(13):12421-12426.
-
Author
- Zaballos A, Villares R, Albar J.P, Martinez-A C, Marquez G.