General Information

    • DRAMP ID

    • DRAMP03391

    • Peptide Name

    • Beta-defensin 36 (BD-36, mBD-36; Defensin, beta 36; Rodents, mammals, animals)

    • Source

    • Mus musculus (Mouse)

    • Family

    • Belongs to the beta-defensin family

    • Gene

    • Defb36

    • Sequence

    • QKCWNLHGKCRHRCSRKESVYVYCTNGKMCCVKPKYQPKPKPWMF

    • Sequence Length

    • 45

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03391 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03391.

Physicochemical Information

    • Formula

    • C242H376N72O58S8

    • Absent Amino Acids

    • ADI

    • Common Amino Acids

    • K

    • Mass

    • 5478.58

    • PI

    • 9.74

    • Basic Residues

    • 13

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +12

    • Boman Index

    • -100.5

    • Hydrophobicity

    • -1.018

    • Aliphatic Index

    • 28

    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 15845

    • Absorbance 280nm

    • 360.11

    • Polar Residues

    • 16

DRAMP03391

DRAMP03391 chydropathy plot

Comments Information

    • PTM

    • Contains three disulfide bonds 3-30; 10-24; 14-31.

Literature Information

  • ·Literature 1

    • Title

    • Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.

    • Reference

    • Physiol Genomics. 2005 Sep 21;23(1):5-17.

    • Author

    • Patil A.A, Cai Y, Sang Y, Blecha F, Zhang G.
  • ·Literature 2

    • Title

    • The transcriptional landscape of the mammalian genome.

    • Reference

    • Science. 2005 Sep 2;309(5740):1559-1563.

    • Author

    • Carninci P, Kasukawa T, Katayama S, Gough J, Frith M.C, et al, Hayashizaki Y.