General Information
-
DRAMP ID
- DRAMP03393
-
Peptide Name
- Beta-defensin 38 (BD-38, mBD-38; Defensin, beta 38; Rodents, mammals, animals)
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Source
- Mus musculus (Mouse)
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Family
- Belongs to the beta-defensin family
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Gene
- Defb38
-
Sequence
- IGPDTKKCVQRKNACHYFECPWLYYSVGTCYKGKGKCCQKRY
-
Sequence Length
- 42
-
UniProt Entry
- Q7TNV7
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
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Target Organism
-
- Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecium.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Bridge
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03393.
Physicochemical Information
-
Formula
- C220H335N61O58S6
Absent Amino Acids
- M
Common Amino Acids
- K
Mass
- 4954.81
PI
- 9.3
Basic Residues
- 10
Acidic Residues
- 2
Hydrophobic Residues
- 7
Net Charge
- +8
-
Boman Index
- -79.36
Hydrophobicity
- -0.836
Aliphatic Index
- 34.76
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 13325
Absorbance 280nm
- 325
Polar Residues
- 19
DRAMP03393
Comments Information
PTM
- Contains three disulfide bonds 8-37; 15-30; 20-38.
Literature Information
- ·Literature 1
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Title
- Identification on mouse chromosome 8 of new beta-defensin genes with regionally specific expression in the male reproductive organ.
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Pubmed ID
- 14718547
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Reference
- J Biol Chem. 2004 Mar 26;279(13):12421-12426.
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Author
- Zaballos A, Villares R, Albar JP, Martínez-A C, Márquez G.