General Information
-
DRAMP ID
- DRAMP03402
-
Peptide Name
- WAP four-disulfide core domain protein 15B (Elafin-like protein I; Rodents, mammals, animals)
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Source
- Mus musculus (Mouse)
-
Family
- Not found
-
Gene
- Wfdc15b
-
Sequence
- RPEIKKKNVFSKPGYCPEYRVPCPFVLIPKCRRDKGCKDALKCCFFYCQMRCVDPWESPE
-
Sequence Length
- 60
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-negative bacterium: Escherichia coli (IC90=10 µM);
- Gram-positive bacterium: Staphylococcus aureus (IC90=10 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03402.
Physicochemical Information
-
Formula
- C319H494N86O82S9
Absent Amino Acids
- HT
Common Amino Acids
- CKP
Mass
- 7134.5
PI
- 9
Basic Residues
- 13
Acidic Residues
- 7
Hydrophobic Residues
- 14
Net Charge
- +6
-
Boman Index
- -125.43
Hydrophobicity
- -0.615
Aliphatic Index
- 47
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 10470
Absorbance 280nm
- 177.46
Polar Residues
- 16
DRAMP03402
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Mouse SWAM1 and SWAM2 are antibacterial proteins composed of a single whey acidic protein motif.
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Pubmed ID
- 12574366
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Reference
- J Immunol. 2003 Feb 15;170(4):1973-1979.
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Author
- Hagiwara K, Kikuchi T, Endo Y, Huqun, Usui K, Takahashi M, Shibata N, Kusakabe T, Xin H, Hoshi S, Miki M, Inooka N, Tokue Y, Nukiwa T.