General Information
-
DRAMP ID
- DRAMP03410
-
Peptide Name
- Neutrophil defensin 3 (HANP-3; alpha-defensin; Rodents, mammals, animals)
-
Source
- Mesocricetus auratus (Golden hamster)
-
Family
- Belongs to the alpha-defensin family
-
Gene
- Not found
-
Sequence
- VTCFCRRRGCASRERLIGYCRFGNTIYGLCCRR
-
Sequence Length
- 33
-
UniProt Entry
- P81467
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- Gram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis;
- Gram-negative bacteria: Escherichia coli, Salmonella serotype krefeld, Klebsiella oxytoca, Pseudomonas aeruginosa.
- Fungi: Candida albicans, Cryptococcus neoformans.
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30.
-
Stereochemistry
- L
-
Structure
- Bridge
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03410.
Physicochemical Information
-
Formula
- C162H266N58O42S6
Absent Amino Acids
- DHKMPQW
Common Amino Acids
- R
Mass
- 3890.62
PI
- 9.8
Basic Residues
- 8
Acidic Residues
- 1
Hydrophobic Residues
- 8
Net Charge
- +7
-
Boman Index
- -98.7
Hydrophobicity
- -0.188
Aliphatic Index
- 59.09
Half Life
-
- Mammalian:100 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 3355
Absorbance 280nm
- 104.84
Polar Residues
- 16
DRAMP03410
Comments Information
Function
- Anti-fungal and bactericidal activity, greater against Gram-positive bacteria.
Literature Information
- ·Literature 1
-
Title
- Isolation, antimicrobial activities, and primary structures of hamster neutrophil defensins.
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Pubmed ID
- 8890190
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Reference
- Infect Immun. 1996 Nov;64(11):4444-4449.
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Author
- Mak P, Wójcik K, Thogersen IB, Dubin A.