• DRAMP ID

    • DRAMP03430
    • Peptide Name

    • Beta-defensin 11 (BD-11, RBD-11; Defensin, beta 11; Rodents, mammals, animals)
    • Source

    • Rattus norvegicus (Rat)
    • Family

    • Belongs to the beta-defensin family
    • Gene

    • Defb11
    • Sequence

    • FLRRSVSGFQECHSKGGYCYRYYCPRPHRRLGSCYPYAANCCRRRR
    • Sequence Length

    • 46
    • Protein Existence

    • Homology
    • Biological Activity

    • Antimicrobial, Antibacterial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03430 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP03430.
    • Formula

    • C240H365N83O61S6
    • Absent Amino Acids

    • DIMTW
    • Common Amino Acids

    • R
    • Mass

    • 5581.42
    • PI

    • 9.99
    • Basic Residues

    • 13
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 7
    • Net Charge

    • +12
    • Boman Index

    • -162.6
    • Hydrophobicity

    • -1.026
    • Aliphatic Index

    • 27.61
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 9315
    • Absorbance 280nm

    • 207
    • Polar Residues

    • 21

DRAMP03430

DRAMP03430 chydropathy plot
    • Function Has antibacterial activity (By similarity).

    • PTM

    • Contains three disulfide bonds 12-41; 19-34; 24-42.
  • ·Literature 1
    • Title

    • Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
    • Reference

    • Physiol Genomics. 2005 Sep 21;23(1):5-17.
    • Author

    • Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.