General Information
-
DRAMP ID
- DRAMP03433
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Peptide Name
- Beta-defensin 14 (BD-14, RBD-14; Defensin, beta 14; Rodents, mammals, animals)
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Source
- Rattus norvegicus (Rat)
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Family
- Belongs to the beta-defensin family
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Gene
- Defb14
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Sequence
- FIPKSLRRFFCRVRGGRCAILNCLGKEEQIGRCSNRGQKCCRKKK
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Sequence Length
- 45
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UniProt Entry
- Q32ZH7
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Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Bridge
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03433.
Physicochemical Information
-
Formula
- C222H381N79O56S6
Absent Amino Acids
- DHMTWY
Common Amino Acids
- R
Mass
- 5245.32
PI
- 10.61
Basic Residues
- 14
Acidic Residues
- 2
Hydrophobic Residues
- 11
Net Charge
- +12
-
Boman Index
- -140.75
Hydrophobicity
- -0.696
Aliphatic Index
- 60.67
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 375
Absorbance 280nm
- 8.52
Polar Residues
- 15
DRAMP03433
Comments Information
Function Has antibacterial activity (By similarity).
PTM
- Contains three disulfide bonds 11-40; 18-33; 23-41.
Literature Information
- ·Literature 1
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Title
- Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
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Pubmed ID
- 16033865
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Reference
- Physiol Genomics. 2005 Sep 21;23(1):5-17.
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Author
- Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.