General Information
-
DRAMP ID
- DRAMP03437
-
Peptide Name
- Beta-defensin 19 (Rodents, mammals, animals)
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Source
- Rattus norvegicus (Rat)
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Family
- Belongs to the beta-defensin family
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Gene
- Defb19
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Sequence
- CRKSCWVIRGHCRKHCRSGERVKKPCSNGDYCCIAKKINTVPQAPKNAFSRNFRVHSRTAPVAVLKNST
-
Sequence Length
- 69
-
UniProt Entry
- Q32ZH3
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03437.
Physicochemical Information
-
Formula
- C332H548N114O90S7
Absent Amino Acids
- M
Common Amino Acids
- KRC
Mass
- 7801.13
PI
- 10.33
Basic Residues
- 19
Acidic Residues
- 2
Hydrophobic Residues
- 18
Net Charge
- +17
-
Boman Index
- -187.22
Hydrophobicity
- -0.68
Aliphatic Index
- 55.07
Half Life
-
- Mammalian:1.2 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 7365
Absorbance 280nm
- 108.31
Polar Residues
- 25
DRAMP03437
Comments Information
Function Has antibacterial activity (By similarity).
Literature Information
- ·Literature 1
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Title
- Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
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Pubmed ID
- 16033865
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Reference
- Physiol Genomics. 2005 Sep 21;23(1):5-17.
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Author
- Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.