General Information
-
DRAMP ID
- DRAMP03439
-
Peptide Name
- Beta-defensin 21 (DEFB21; Protein Defb21; rodents, mammals, animals)
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Source
- Rattus norvegicus (Rat)
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Family
- Belongs to the beta-defensin family
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Gene
- Defb21
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Sequence
- MRLLLMALPLLALLPQVIPDYSAEKRCLNRLGHCKRKCKAGEMVMETCKYFQVCCVLDDNDYKQKASITRTMEKTSTIEYNLS
-
Sequence Length
- 83
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UniProt Entry
- Q32ZH1
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03439.
Physicochemical Information
-
Formula
- C416H690N114O121S11
Absent Amino Acids
- W
Common Amino Acids
- L
Mass
- 9577.41
PI
- 8.8
Basic Residues
- 14
Acidic Residues
- 9
Hydrophobic Residues
- 25
Net Charge
- +5
-
Boman Index
- -132.84
Hydrophobicity
- -0.177
Aliphatic Index
- 90.48
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 6335
Absorbance 280nm
- 77.26
Polar Residues
- 24
DRAMP03439
Comments Information
Function Has antibacterial activity (By similarity).
Literature Information
- ·Literature 1
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Title
- Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
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Pubmed ID
- 16033865
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Reference
- Physiol Genomics. 2005 Sep 21;23(1):5-17.
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Author
- Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.