General Information
-
DRAMP ID
- DRAMP03441
-
Peptide Name
- Beta-defensin 25 (BD-25, RBD-25; Defensin, beta 25; Rodents, mammals, animals)
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Source
- Rattus norvegicus (Rat)
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Family
- Belongs to the beta-defensin family
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Gene
- Defb25
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Sequence
- EFKRCWNGQGACRTYCTRQEKFIHLCPDASLCCLSYSLKASPHSRAGGV
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Sequence Length
- 49
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UniProt Entry
- Q32ZG7
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Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Bridge
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03441.
Physicochemical Information
-
Formula
- C235H366N72O68S6
Absent Amino Acids
- M
Common Amino Acids
- C
Mass
- 5480.29
PI
- 8.91
Basic Residues
- 9
Acidic Residues
- 3
Hydrophobic Residues
- 13
Net Charge
- +6
-
Boman Index
- -92.52
Hydrophobicity
- -0.39
Aliphatic Index
- 53.88
Half Life
-
- Mammalian:1 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 8855
Absorbance 280nm
- 184.48
Polar Residues
- 20
DRAMP03441
Comments Information
Function Has antibacterial activity (By similarity).
PTM
- Contains three disulfide bonds 5-32; 12-26; 16-33.
Literature Information
- ·Literature 1
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Title
- Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
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Pubmed ID
- 16033865
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Reference
- Physiol Genomics. 2005 Sep 21;23(1):5-17.
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Author
- Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.