General Information
-
DRAMP ID
- DRAMP03444
-
Peptide Name
- Beta-defensin 29 (BD-29, RBD-29; Defensin, beta 29; Rodents, mammals, animals)
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Source
- Rattus norvegicus (Rat)
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Family
- Belongs to the beta-defensin family
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Gene
- Defb29
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Sequence
- GLFGLRSGKRREPWVSCELYQGSCRNACQKYEIQYLTCPKKRKCCLKFPMKITRV
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Sequence Length
- 55
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UniProt Entry
- Q32ZG3
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Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Bridge
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03444.
Physicochemical Information
-
Formula
- C286H465N85O74S7
Absent Amino Acids
- DH
Common Amino Acids
- KCR
Mass
- 6502.78
PI
- 9.79
Basic Residues
- 13
Acidic Residues
- 3
Hydrophobic Residues
- 13
Net Charge
- +10
-
Boman Index
- -121.41
Hydrophobicity
- -0.602
Aliphatic Index
- 62
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 10345
Absorbance 280nm
- 191.57
Polar Residues
- 19
DRAMP03444
Comments Information
Function Has antibacterial activity (By similarity).
PTM
- Contains three disulfide bonds 17-44; 24-38; 28-45.
Literature Information
- ·Literature 1
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Title
- Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
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Pubmed ID
- 16033865
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Reference
- Physiol Genomics. 2005 Sep 21;23(1):5-17.
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Author
- Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.