General Information
-
DRAMP ID
- DRAMP03453
-
Peptide Name
- Beta-defensin 43 (BD-43, RBD-43; Defensin, beta 43; Rodents, mammals, animals)
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Source
- Rattus norvegicus (Rat)
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Family
- Belongs to the beta-defensin family
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Gene
- Defb43
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Sequence
- FLANQECFSEYRHCRMKCKANEYAIRYCADWTICCRVKKREAKKKIMW
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Sequence Length
- 48
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UniProt Entry
- Q32ZF3
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Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Bridge
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03453.
Physicochemical Information
-
Formula
- C261H409N77O67S8
Absent Amino Acids
- GP
Common Amino Acids
- K
Mass
- 5954.07
PI
- 9.35
Basic Residues
- 13
Acidic Residues
- 5
Hydrophobic Residues
- 14
Net Charge
- +8
-
Boman Index
- -123.51
Hydrophobicity
- -0.694
Aliphatic Index
- 48.96
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 15845
Absorbance 280nm
- 337.13
Polar Residues
- 13
DRAMP03453
Comments Information
Function Has antibacterial activity (By similarity).
PTM
- Contains two disulfide bonds 7-35; 14-28.
Literature Information
- ·Literature 1
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Title
- Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
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Pubmed ID
- 16033865
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Reference
- Physiol Genomics. 2005 Sep 21;23(1):5-17.
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Author
- Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.