General Information
-
DRAMP ID
- DRAMP03456
-
Peptide Name
- Beta-defensin 50 (BD-50, RBD-50; Defensin, beta 50; Rodents, mammals, animals)
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Source
- Rattus norvegicus (Rat)
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Family
- Belongs to the beta-defensin family
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Gene
- Defb50
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Sequence
- HPGTVHVRFKCIPKIAAVFGDNCPFYGNVDGLCNDKKSVCCMVPVRLDNI
-
Sequence Length
- 50
-
UniProt Entry
- Q30KJ2
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Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Bridge
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03456.
Physicochemical Information
-
Formula
- C242H382N68O66S6
Absent Amino Acids
- EQW
Common Amino Acids
- V
Mass
- 5492.47
PI
- 8.4
Basic Residues
- 8
Acidic Residues
- 4
Hydrophobic Residues
- 17
Net Charge
- +4
-
Boman Index
- -50.96
Hydrophobicity
- 0.142
Aliphatic Index
- 83.6
Half Life
-
- Mammalian:3.5 hour
- Yeast:10 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1740
Absorbance 280nm
- 35.51
Polar Residues
- 16
DRAMP03456
Comments Information
Function Has antibacterial activity (By similarity).
PTM
- Contains two disulfide bonds 11-40; 23-41.
Literature Information
- ·Literature 1
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Title
- Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
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Pubmed ID
- 16033865
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Reference
- Physiol Genomics. 2005 Sep 21;23(1):5-17.
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Author
- Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.
- ·Literature 2
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Title
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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Pubmed ID
- 15489334
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Reference
- Genome Res. 2004 Oct;14(10B):2121-2127.
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Author
- Gerhard DS, Wagner L, et al.