General Information

    • DRAMP ID

    • DRAMP03463

    • Peptide Name

    • rCRAMP (rat cathelin-related antimicrobial peptide; Rodents, mammals, animals)

    • Source

    • Rattus norvegicus (Norway rat)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLVRKGGEKFGEKLRKIGQKIKEFFQKLALEIEQ

    • Sequence Length

    • 34

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

      • [No NaCl]: Escherichia coli DH5a (MIC=0.54 µM), E. coli ML-35p (MIC=1.55 µM), Pseudomonas aeruginosa PAO1 (MIC=0.69 µM), Pseudomonas aeruginosa MR3007 (MIC=2.01 µM); Staphylococcus aureus ATCC (MRSA) 33591 (MIC=3.19 µM), Staphylococcus aureus 93918 (MIC=2.14 µM).
      • [100 mM NaCl]: Escherichia coli DH5a (MIC=0.61 µM), Escherichia coli ML-35p (MIC=0.66 µM), Pseudomonas aeruginosa PAO1 (MIC=1.17 µM), Pseudomonas aeruginosa MR3007 (MIC=1.78 µM), Staphylococcus aureus ATCC (MRSA) 33591 (MIC>20.1 µM), Staphylococcus aureus 93918 (MIC=2.16 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03463 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C181H302N50O48

    • Absent Amino Acids

    • CDHMNPSTWY

    • Common Amino Acids

    • K

    • Mass

    • 3946.7

    • PI

    • 9.87

    • Basic Residues

    • 9

    • Acidic Residues

    • 5

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +4

    • Boman Index

    • -65.43

    • Hydrophobicity

    • -0.682

    • Aliphatic Index

    • 91.76

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP03463

DRAMP03463 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Bactericidal activity of mammalian cathelicidin-derived peptides.

    • Reference

    • Infect Immun. 2000 May;68(5):2748-2755.

    • Author

    • Travis SM, Anderson NN, Forsyth WR, Espiritu C, Conway BD, Greenberg EP, McCray PB Jr, Lehrer RI, Welsh MJ, Tack BF.