General Information

    • DRAMP ID

    • DRAMP03464

    • Peptide Name

    • Cryptonin (Insects, animals)

    • Source

    • Cryptotympana dubia (Korean horse cicada)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLLNGLALRLGKRALKKIIKRLCR

    • Sequence Length

    • 24

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.18000874]Gram-positive bacteria: Bacillus subtilis KCTC 3086 (MIC=3.12 µg/ml), Staphylococcus aureus KCTC 1928 (MIC=25 µg/ml), Micrococcus luteus KCTC 3063 (MIC=1.56 µg/ml), Staphylococcus aureus (MRSA) (MIC=25 µg/ml), VRE (MIC=25 µg/ml);
      • Gram-negative bacteria: Escherichia coli K12-594 (MIC=3.12 µg/ml);
      • Fungi: Candida albicans KCTC 7965 (MIC=50 µg/ml), Candida tropicalis KCTC 1925 (MIC=3.12 µg/ml).

    • Hemolytic Activity

      • [Ref.18000874]<5% hemolytic activity at 25-200 µg/ml against rat erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03464 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C121H227N41O26S

    • Absent Amino Acids

    • DEFHMPQSTVWY

    • Common Amino Acids

    • L

    • Mass

    • 2704.45

    • PI

    • 12.02

    • Basic Residues

    • 8

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +8

    • Boman Index

    • -36.52

    • Hydrophobicity

    • 0.142

    • Aliphatic Index

    • 154.58

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP03464

DRAMP03464 chydropathy plot

Comments Information

    • Function

    • Has very low hemolytic activity on rat erythrocytes.

Literature Information

  • ·Literature 1

    • Title

    • Isolation and functional analysis of a 24-residue linear alpha-helical antimicrobial peptide from Korean blackish cicada, Cryptotympana dubia (Homoptera).

    • Reference

    • Arch Insect Biochem Physiol. 2007 Dec;66(4):204-213.

    • Author

    • Leem JY, Park DS, Suh EY, Hur JH, Oh HW, Park HY.