• DRAMP ID

    • DRAMP03464
    • Peptide Name

    • Cryptonin (Insects, animals)
    • Source

    • Cryptotympana dubia (Korean horse cicada)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GLLNGLALRLGKRALKKIIKRLCR
    • Sequence Length

    • 24
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • [Ref.18000874]Gram-positive bacteria: Bacillus subtilis KCTC 3086 (MIC=3.12 µg/ml), Staphylococcus aureus KCTC 1928 (MIC=25 µg/ml), Micrococcus luteus KCTC 3063 (MIC=1.56 µg/ml), Staphylococcus aureus (MRSA) (MIC=25 µg/ml), VRE (MIC=25 µg/ml);
      • Gram-negative bacteria: Escherichia coli K12-594 (MIC=3.12 µg/ml);
      • Fungi: Candida albicans KCTC 7965 (MIC=50 µg/ml), Candida tropicalis KCTC 1925 (MIC=3.12 µg/ml).
    • Hemolytic Activity

      • [Ref.18000874]<5% hemolytic activity at 25-200 µg/ml against rat erythrocytes
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Alpha helix
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03464 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C121H227N41O26S
    • Absent Amino Acids

    • DEFHMPQSTVWY
    • Common Amino Acids

    • L
    • Mass

    • 2704.45
    • PI

    • 12.02
    • Basic Residues

    • 8
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 11
    • Net Charge

    • +8
    • Boman Index

    • -36.52
    • Hydrophobicity

    • 0.142
    • Aliphatic Index

    • 154.58
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 5

DRAMP03464

DRAMP03464 chydropathy plot
    • Function

    • Has very low hemolytic activity on rat erythrocytes.
  • ·Literature 1
    • Title

    • Isolation and functional analysis of a 24-residue linear alpha-helical antimicrobial peptide from Korean blackish cicada, Cryptotympana dubia (Homoptera).
    • Reference

    • Arch Insect Biochem Physiol. 2007 Dec;66(4):204-213.
    • Author

    • Leem JY, Park DS, Suh EY, Hur JH, Oh HW, Park HY.