General Information
-
DRAMP ID
- DRAMP03465
-
Peptide Name
- Cicadin (Insects, animals)
-
Source
- Cicada flammata
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- NEYHGFVDKANNENKRKKQQGRDDFVVKPNNFANRRRKDDYNENYYDDVDAADVV
-
Sequence Length
- 55
-
UniProt Entry
- P83282
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal, Antiviral
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Target Organism
-
- Fungi: Botrytis cinerea (MIC=100 nM), Mycosphaerella arachidicola (MIC=70 nM), Fusarium oxysporum (MIC=180 nM), Physalospora piricola (MIC=60 nM), Rhizoctonia solani, Coprinus comatus, HIV-1 reverse transcriptase.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03465.
Physicochemical Information
-
Formula
- C283H427N89O95
Absent Amino Acids
- CILMSTW
Common Amino Acids
- DN
Mass
- 6596.04
PI
- 5.7
Basic Residues
- 12
Acidic Residues
- 12
Hydrophobic Residues
- 13
Net Charge
- 0
-
Boman Index
- -240.57
Hydrophobicity
- -1.753
Aliphatic Index
- 38.91
Half Life
-
- Mammalian:1.4 hour
- Yeast:3 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5960
Absorbance 280nm
- 110.37
Polar Residues
- 15
DRAMP03465
Comments Information
Function
- Possesses antifungal activity against B.cinerea, M.arachidicola, F.oxysporum, R.solani and C.comatus. Suppresses the activity of HIV-1 reverse transcriptase and stimulates the proliferation of murine splenocytes.
Literature Information
- ·Literature 1
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Title
- Isolation of cicadin, a novel and potent antifungal peptide from dried juvenile cicadas.
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Pubmed ID
- 11814612
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Reference
- Peptides. 2002;23:7-11.
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Author
- Wang H, Ng TB.