General Information

    • DRAMP ID

    • DRAMP03466

    • Peptide Name

    • Ribosome-inactivating protein luffacylin (rRNA N-glycosidase; Plants)

    • Source

    • Luffa cylindrica (Smooth loofah) (Sponge gourd)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • PRGSPRTEYEAARR

    • Sequence Length

    • 14

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Mycosphaerella arachidicola, Fusarium oxysporum.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03466 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03466.

Physicochemical Information

    • Formula

    • C68H112N26O22

    • Absent Amino Acids

    • CDFHIKLMNQVW

    • Common Amino Acids

    • R

    • Mass

    • 1645.8

    • PI

    • 10.67

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +2

    • Boman Index

    • -74.85

    • Hydrophobicity

    • -1.986

    • Aliphatic Index

    • 14.29

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 114.62

    • Polar Residues

    • 4

DRAMP03466

Comments Information

    • Function

    • Has antifungal activity against F. oxysporum and M. arachidicola. Inhibits cell-free translation in rabbit reticulocyte lysate system. Has some N-glycosidase activity.

    • Catalytic activity

    • Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

Literature Information

  • ·Literature 1

    • Title

    • Isolation and characterization of luffacylin, a ribosome inactivating peptide with anti-fungal activity from sponge gourd (Luffa cylindrica) seeds.

    • Reference

    • Peptides. 2002 Jun;23(6):1019-10124.

    • Author

    • Parkash A, Ng TB, Tso WW.