General Information

    • DRAMP ID

    • DRAMP03477

    • Peptide Name

    • Polybia-CP (Polybia chemotactic peptide; Venom protein CP; Insects, animals)

    • Source

    • Polybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ILGTILGLLKSL

    • Sequence Length

    • 12

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Bacillus subtilis CCT 2576 (MIC=15 µg/ml), Staphylococcus aureus ATCC 6538 (MIC=15 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03477 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03477.

Physicochemical Information

    • Formula

    • C59H109N13O15

    • Absent Amino Acids

    • ACDEFHMNPQRVWY

    • Common Amino Acids

    • L

    • Mass

    • 1240.59

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +1

    • Boman Index

    • 24.8

    • Hydrophobicity

    • 1.817

    • Aliphatic Index

    • 227.5

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP03477

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Structural and functional characterization of two novel peptide toxins isolated from the venom of the social wasp Polybia paulista.

    • Reference

    • Peptides. 2005 Nov;26(11):2157-2164.

    • Author

    • Souza BM, Mendes MA, Santos LD, Marques MR, César LM, Almeida RN, Pagnocca FC, Konno K, Palma MS.
  • ·Literature 2

    • Title

    • D-amino acid substitution enhances the stability of antimicrobial peptide polybia-CP.

    • Reference

    • Acta Biochim Biophys Sin (Shanghai). 2017 Oct 1;49(10):916-925.

    • Author

    • Jia F, Wang J, Peng J, Zhao P, Kong Z, Wang K, Yan W, Wang R.