General Information

    • DRAMP ID

    • DRAMP03508

    • Peptide Name

    • Yamamarin (Growth-suppressing pentapeptide; Plant defensin; Insects, animals)

    • Source

    • Antheraea yamamai (Japanese oak silkmoth)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DILRG

    • Sequence Length

    • 5

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Unknown

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03508 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03508.

Physicochemical Information

    • Formula

    • C24H44N8O8

    • Absent Amino Acids

    • ACEFHKMNPQSTVWY

    • Common Amino Acids

    • DGILR

    • Mass

    • 572.66

    • PI

    • 5.84

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 2

    • Net Charge

    • 0

    • Boman Index

    • -12.86

    • Hydrophobicity

    • -0.02

    • Aliphatic Index

    • 156

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP03508

Comments Information

    • Function

    • Suppresses growth in rat hepatoma cells and maintains diapause in insects.

    • Developmental stage

    • Diapause.

    • PTM

    • Diapausing first instar larvae contain both amidated and non-amidated forms.

Literature Information

  • ·Literature 1

    • Title

    • Growth suppression of rat heptatoma cells by a pentapeptide from Antheraea yamamai.

    • Reference

    • J. Insect Biotechnol. Sericology. 2004;73:7-13.

    • Author

    • Yang P, Abe S, Zhao Y, An Y, Suzuki K.
  • ·Literature 2

    • Title

    • A palmitonyl conjugate of an insect pentapeptide causes growth arrest in mammalian cells and mimics the action of diapause hormone.

    • Reference

    • J. Insect Biotechnol. Sericology. 2007;76:63-69.

    • Author

    • Yang P, Abe S, Sato Y, Yamashita T, Matsuda F, Hamayasu T, Imai K, Suzuki K.