General Information

    • DRAMP ID

    • DRAMP03513

    • Peptide Name

    • G. mellonella moricin-like peptide A (Gm-mlpA; Insects, animals; Predicted)

    • Source

    • Galleria mellonella (Greater wax moth)

    • Family

    • Not found

    • Gene

    • mor

    • Sequence

    • KVNVNAIKKGGKAIGKGFKVISAASTAHDVYEHIKNRRH

    • Sequence Length

    • 39

    • Protein Existence

    • Predicted

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=10 µM);
      • Gram-positive bacterium: Micrococcus luteus (MIC=10 µM).
      • Fungi: Fusarium graminearum mycelia (MIC=70 µM), F;
      • Graminearum spores (MIC=0.7 µM), Fusarium oxysporum mycelia (MIC=7 µM), F. oxysporum spores (MIC=10 µM), Ascochyta rabiei spores (MIC=7 µM), Leptosphaeria maculans spores (MIC=7 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03513 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C188H313N61O51

    • Absent Amino Acids

    • CLMPQW

    • Common Amino Acids

    • K

    • Mass

    • 4243.93

    • PI

    • 10.46

    • Basic Residues

    • 12

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +10

    • Boman Index

    • -76

    • Hydrophobicity

    • -0.564

    • Aliphatic Index

    • 82.56

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 39.21

    • Polar Residues

    • 11

DRAMP03513

DRAMP03513 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella.

    • Reference

    • Insect Biochem Mol Biol. 2008;38:201-212.

    • Author

    • Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD.