General Information

    • DRAMP ID

    • DRAMP03521

    • Peptide Name

    • Proline-rich antimicrobial peptide 1 (Insects, animals)

    • Source

    • Galleria mellonella (Greater wax moth)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DIQIPGIKKPTHRDIIIPNWNPNVRTQPWQRFGGNKS

    • Sequence Length

    • 37

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal

    • Target Organism

      • Gram-positive bacterium: Micrococcus luteus(MIC=55.0 µM).
      • Fungi: Pichia pastoris (MIC=16.5 µM), Zygosaccharomyces marxianus (MIC=16.5 µM), Schizosaccharomyces pombe (MIC=11 µM), candida wickerhamii (MIC=16.5 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03521 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03521.

Physicochemical Information

    • Formula

    • C195H306N60O52

    • Absent Amino Acids

    • ACELMY

    • Common Amino Acids

    • I

    • Mass

    • 4322.95

    • PI

    • 11

    • Basic Residues

    • 7

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +5

    • Boman Index

    • -91.21

    • Hydrophobicity

    • -1.057

    • Aliphatic Index

    • 71.08

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 305.56

    • Polar Residues

    • 10

DRAMP03521

DRAMP03521 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial peptides of the moth Galleria mellonella.

    • Reference

    • Acta Biochim Pol. 2001;48(4):1191-1195.

    • Author

    • Mak P, Chmiel D, Gacek GJ.
  • ·Literature 2

    • Title

    • Purification and characterization of eight peptides from Galleria mellonella immune hemolymph.

    • Reference

    • Peptides. 2007 Mar;28(3):533-546.

    • Author

    • Cytrynska M, Mak P, Zdybicka-Barabas A, Suder P, Jakubowicz T.