General Information

    • DRAMP ID

    • DRAMP03542

    • Peptide Name

    • Neurokinin A (NKA; chicken, animals)

    • Source

    • Gallus gallus (Chicken)

    • Family

    • Belongs to the tachykinin family.

    • Gene

    • Not found

    • Sequence

    • HKTDSFVGLM

    • Sequence Length

    • 10

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Neuropeptide, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.18603306] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>500 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC>500 μg/ml) ;
      • Gram-positive bacteria: Streptococcus mutans NCTC 10449 (MIC> 500 μg/ml), Lactobacillus acidophilus NCTC 1723 (MIC>500 μg/ml), Enterococcus faecalis NCTC 12697 (MIC>500 μg/ml), Staphylococcus aureus ATCC 25923 (MIC>500 μg/ml);
      • Yeast: Candida albicans NCTC 3179 (MIC>500 μg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03542 helical wheel diagram

    • PDB ID

    • 1N6T resolved by NMR.

    • Predicted Structure

    • There is no predicted structure for DRAMP03542.

Physicochemical Information

    • Formula

    • C50H79N13O15S

    • Absent Amino Acids

    • ACEINPQRWY

    • Common Amino Acids

    • DFGHKLMST

    • Mass

    • 1134.32

    • PI

    • 6.74

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +1

    • Boman Index

    • -9.67

    • Hydrophobicity

    • 0.02

    • Aliphatic Index

    • 68

    • Half Life

      • Mammalian:3.5 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP03542

Comments Information

    • Function

    • Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Antibacterial activity is very low.

    • PTM

    • Methionine amide at position 10.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites.

    • Reference

    • J Neuroimmunol. 2008 Aug 30;200(1-2):11-16.

    • Author

    • El Karim IA, Linden GJ, Orr DF, Lundy FT.