General Information

    • DRAMP ID

    • DRAMP03550

    • Peptide Name

    • Beta-amyloid peptide 42 (Human, mammals, animals)

    • Source

    • Homo sapiens (Human)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

    • Sequence Length

    • 42

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Not found

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03550 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP03550.

Physicochemical Information

    • Formula

    • C203H311N55O60S

    • Absent Amino Acids

    • CPTW

    • Common Amino Acids

    • GV

    • Mass

    • 4514.1

    • PI

    • 5.31

    • Basic Residues

    • 6

    • Acidic Residues

    • 6

    • Hydrophobic Residues

    • 18

    • Net Charge

    • 0

    • Boman Index

    • -32.7

    • Hydrophobicity

    • 0.205

    • Aliphatic Index

    • 97.38

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 36.34

    • Polar Residues

    • 10

DRAMP03550

DRAMP03550 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.

    • Reference

    • PLoS One. 2010 Mar 3;5(3):e9505.

    • Author

    • Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE, Moir RD.