General Information

    • DRAMP ID

    • DRAMP03576

    • Peptide Name

    • Histatin-1 (His-rich; Human, mammals, animals)

    • Source

    • Homo sapiens (Human)

    • Family

    • Not found

    • Gene

    • HTN1

    • Sequence

    • DSHEKRHHGYRRKFHEKHHSHREFPFYGDYGSNYLYDN

    • Sequence Length

    • 38

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Yeast: Candida albicans (99.5±0.5 % inhibition at 54 nmol).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03576 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03576.

Physicochemical Information

    • Formula

    • C217H297N69O61

    • Absent Amino Acids

    • ACIMQTVW

    • Common Amino Acids

    • H

    • Mass

    • 4848.17

    • PI

    • 8.32

    • Basic Residues

    • 14

    • Acidic Residues

    • 6

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +8

    • Boman Index

    • -163.04

    • Hydrophobicity

    • -2.095

    • Aliphatic Index

    • 10.26

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 7450

    • Absorbance 280nm

    • 201.35

    • Polar Residues

    • 13

DRAMP03576

DRAMP03576 chydropathy plot

Comments Information

    • PTM

    • Phosphoserine at position 2; And Sulfotyrosine at position 27,30,34,36.

Literature Information

  • ·Literature 1

    • Title

    • Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.

    • Reference

    • J Biol Chem. 1988 Jun 5;263(16):7472-7477

    • Author

    • Oppenheim FG, Xu T, McMillian FM, Levitz SM, Diamond RD, Offner GD, Troxler RF.