General Information

    • DRAMP ID

    • DRAMP03577

    • Peptide Name

    • Histatin-2 (His-rich; Human, mammals, animals)

    • Source

    • Homo sapiens (Human)

    • Family

    • Not found

    • Gene

    • HTN3

    • Sequence

    • RKFHEKHHSHREFPFYGDYGSNYLYDN

    • Sequence Length

    • 27

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03577 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03577.

Physicochemical Information

    • Formula

    • C158H211N45O44

    • Absent Amino Acids

    • ACIMQTVW

    • Common Amino Acids

    • HY

    • Mass

    • 3444.69

    • PI

    • 7.1

    • Basic Residues

    • 8

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +4

    • Boman Index

    • -95.54

    • Hydrophobicity

    • -1.763

    • Aliphatic Index

    • 14.44

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5960

    • Absorbance 280nm

    • 229.23

    • Polar Residues

    • 10

DRAMP03577

DRAMP03577 chydropathy plot

Comments Information

    • An autoproteolytic product from Histatin 1 but not phosphorylated (Lal et al. 1992 Arch Oral Bio 37

    • 7-13).

Literature Information

  • ·Literature 1

    • Title

    • Histatins 2 and 4 are autoproteolytic degradation products of human parotid saliva.

    • Reference

    • Oral Microbiol Immunol 1992; 7: 127-128.

    • Author

    • Xu L, Lal K, Pollock JJ.