General Information

    • DRAMP ID

    • DRAMP03579

    • Peptide Name

    • Histatin-4 (His-rich; Human, mammals, animals)

    • Source

    • Homo sapiens (Human)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RKFHEKHHSHRGYRSNYLYDN

    • Sequence Length

    • 21

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03579 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03579.

Physicochemical Information

    • Formula

    • C121H174N42O33

    • Absent Amino Acids

    • ACIMPQTVW

    • Common Amino Acids

    • H

    • Mass

    • 2744.97

    • PI

    • 9.82

    • Basic Residues

    • 9

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +7

    • Boman Index

    • -101.69

    • Hydrophobicity

    • -2.257

    • Aliphatic Index

    • 18.57

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 4470

    • Absorbance 280nm

    • 223.5

    • Polar Residues

    • 8

DRAMP03579

DRAMP03579 chydropathy plot

Comments Information

    • An autoproteolytic product from Histatin 3.

Literature Information

  • ·Literature 1

    • Title

    • Histatins 2 and 4 are autoproteolytic degradation products of human parotid saliva.

    • Reference

    • Oral Microbiol Immunol 1992; 7: 127-128.

    • Author

    • Xu L, Lal K, Pollock JJ.