General Information

    • DRAMP ID

    • DRAMP03580

    • Peptide Name

    • His3-(20-43)-peptide (Histatin 5; derivatives: Dh-5; Clinical)

    • Source

    • Homo sapiens (Human)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DSHAKRHHGYKRKFHEKHHSHRGY

    • Sequence Length

    • 24

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

      • Yeast: Candida albicans (100% inhibition at 54 nmol), Cryptococcus neoformans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Metal-binding (Zinc)

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03580 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03580.

Physicochemical Information

    • Formula

    • C133H195N51O33

    • Absent Amino Acids

    • CILMNPQTVW

    • Common Amino Acids

    • H

    • Mass

    • 3036.33

    • PI

    • 10.28

    • Basic Residues

    • 14

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +12

    • Boman Index

    • -115.52

    • Hydrophobicity

    • -2.454

    • Aliphatic Index

    • 4.17

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 2980

    • Absorbance 280nm

    • 129.57

    • Polar Residues

    • 6

DRAMP03580

DRAMP03580 chydropathy plot

Comments Information

    • Histatin 5 is a proteolytic product of histatin 3. The active Domain

    • of histitin 5 (Dh-5) corresponding to residues 11-24 showed HIV inhibitory effects. However,the results with the Dh-5 mutants are mixed (Groot et al. 2006 J. Virol. 80

Literature Information

  • ·Literature 1

    • Title

    • Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.

    • Reference

    • J Biol Chem. 1988 Jun 5;263(16):7472-7477.

    • Author

    • Oppenheim FG, Xu T, McMillian FM, Levitz SM, Diamond RD, Offner GD, Troxler RF.