General Information

    • DRAMP ID

    • DRAMP03583

    • Peptide Name

    • Histatin 8 (His-rich; Human, mammals, animals)

    • Source

    • Homo sapiens (Human)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KFHEKHHSHRGY

    • Sequence Length

    • 12

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03583 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03583.

Physicochemical Information

    • Formula

    • C70H99N25O17

    • Absent Amino Acids

    • ACDILMNPQTVW

    • Common Amino Acids

    • H

    • Mass

    • 1562.71

    • PI

    • 9.7

    • Basic Residues

    • 7

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 1

    • Net Charge

    • +6

    • Boman Index

    • -51.09

    • Hydrophobicity

    • -2.358

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 135.45

    • Polar Residues

    • 3

DRAMP03583

Comments Information

    • It is the fragment of histatin 5.

Literature Information

  • ·Literature 1

    • Title

    • Physical parameters of hydroxyapatite adsorption and effect on candidacidal activity of histatins.

    • Reference

    • Arch Oral Biol 2003 May;48(5):361-368.

    • Author

    • Yin A, Margolis HC, Grogan J, Yao Y, Troxler RF, Oppenheim FG.