General Information

    • DRAMP ID

    • DRAMP03588

    • Peptide Name

    • Human MUC7 20-Mer (Human, mammals, animals)

    • Source

    • Homo sapiens (Human)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LAHQKPFIRKSYKCLHKRCR

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Streptococcus mutans (EC50=1.39 µM), Streptococcus gordonii (EC50=2.43 µM);
      • Gram-negative bacteria: Escherichia coli (EC50=1.61 µM), Pseudomonas aeruginosa (EC50=4.41 µM), Porphyromonas gingivalis (EC50<1 µM).
      • Fungi: Candida albicans (DIS) (EC50=5.85 µM), C. albicans (azole resistant) (EC50=2.40 µM), Candida glabrata (EC50=5.02 µM), C. glabrata (fluconazole resistant) (EC50=12.3 µM), Candida krusei (EC50=5.16 µM), Cryptococcus neoformans (EC50=4.05 µM), Cryptococcus neoformans (amphotericin B resistant) (EC50=4.29 µM), Saccharomyces cerevisiae (EC50=5.23 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03588 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03588.

Physicochemical Information

    • Formula

    • C112H186N38O24S2

    • Absent Amino Acids

    • DEGMNTVW

    • Common Amino Acids

    • K

    • Mass

    • 2513.07

    • PI

    • 10.57

    • Basic Residues

    • 9

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +9

    • Boman Index

    • -63.25

    • Hydrophobicity

    • -1.05

    • Aliphatic Index

    • 63.5

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1615

    • Absorbance 280nm

    • 85

    • Polar Residues

    • 4

DRAMP03588

DRAMP03588 chydropathy plot

Comments Information

    • Function

    • MUC7 20-mer showes potent activity against a variety of fungi, including C. albicans, C. glabrata, C. krusei, C. neoformans, and S. cerevisae. In addition, it is also active against several drug-resistant strains, including azole-resistant C. albicans, fluconazole-resistant C. glabrata, and amphotericin B-resistant C. neoformans.

Literature Information

  • ·Literature 1

    • Title

    • MUC7 20-Mer: Investigation of Antimicrobial Activity, Secondary Structure, and Possible Mechanism of Antifungal Action.

    • Reference

    • Antimicrob Agents Chemother 2003 Feb;47(2):643-652.

    • Author

    • Bobek LA, Situ H.