General Information

    • DRAMP ID

    • DRAMP03608

    • Peptide Name

    • Beta-defensin 108B (Beta-defensin 8; hBD-8; Defensin, beta 108B; Human, mammals, animals)

    • Source

    • Homo sapiens (Human)

    • Family

    • Belongs to the beta-defensin family

    • Gene

    • DEFB108B

    • Sequence

    • KFKEICERPNGSCRDFCLETEIHVGRCLNSQPCCLPLGHQPRIESTTPKKD

    • Sequence Length

    • 51

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03608 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03608.

Physicochemical Information

    • Formula

    • C246H399N75O76S6

    • Absent Amino Acids

    • AMWY

    • Common Amino Acids

    • CEP

    • Mass

    • 5815.69

    • PI

    • 7.79

    • Basic Residues

    • 10

    • Acidic Residues

    • 7

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +3

    • Boman Index

    • -130.02

    • Hydrophobicity

    • -0.759

    • Aliphatic Index

    • 59.22

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 7.5

    • Polar Residues

    • 17

DRAMP03608

DRAMP03608 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activity.

    • PTM

    • Contains three disulfide bonds (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Discovery of five conserved beta-defensin gene clusters using a computational search strategy.

    • Reference

    • Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2129-2133.

    • Author

    • Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr.