General Information

    • DRAMP ID

    • DRAMP03614

    • Peptide Name

    • Beta-defensin 115 (Beta-defensin 15, DEFB-15; Defensin, beta 115; Human, mammals, animals)

    • Source

    • Homo sapiens (Human)

    • Family

    • Belongs to the beta-defensin family

    • Gene

    • DEFB115

    • Sequence

    • QTAPDGWIRRCYYGTGRCRKSCKEIERKKEKCGEKHICCVPKEKDKLSHIHDQKETSELYI

    • Sequence Length

    • 61

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03614 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03614.

Physicochemical Information

    • Formula

    • C310H503N95O93S6

    • Absent Amino Acids

    • FMN

    • Common Amino Acids

    • K

    • Mass

    • 7241.34

    • PI

    • 8.97

    • Basic Residues

    • 18

    • Acidic Residues

    • 10

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +8

    • Boman Index

    • -193.26

    • Hydrophobicity

    • -1.248

    • Aliphatic Index

    • 51.15

    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 10345

    • Absorbance 280nm

    • 172.42

    • Polar Residues

    • 19

DRAMP03614

DRAMP03614 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activity.

    • PTM

    • Contains three disulfide bonds (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.

    • Reference

    • Physiol Genomics. 2005 Sep 21;23(1):5-17.

    • Author

    • Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.
  • ·Literature 2

    • Title

    • The DNA sequence and comparative analysis of human chromosome 20.

    • Reference

    • Nature. 2001 Dec 20-27;414(6866):865-871.

    • Author

    • Deloukas P, Matthews LH, Ashurst J, Burton J, et al, Rogers J.