• DRAMP ID

    • DRAMP03620
    • Peptide Name

    • Beta-defensin 124 (Beta-defensin 24, DEFB-24; Defensin, beta 124; Human, mammals, animals)
    • Source

    • Homo sapiens (Human)
    • Family

    • Belongs to the beta-defensin family
    • Gene

    • DEFB124
    • Sequence

    • EFKRCWKGQGACQTYCTRQETYMHLCPDASLCCLSYALKPPPVPKHEYE
    • Sequence Length

    • 49
    • Protein Existence

    • Transcript level
    • Biological Activity

    • Antimicrobial, Antibacterial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03620 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP03620.
    • Formula

    • C251H379N67O72S7
    • Absent Amino Acids

    • IN
    • Common Amino Acids

    • C
    • Mass

    • 5711.6
    • PI

    • 7.84
    • Basic Residues

    • 8
    • Acidic Residues

    • 5
    • Hydrophobic Residues

    • 10
    • Net Charge

    • +3
    • Boman Index

    • -82.64
    • Hydrophobicity

    • -0.676
    • Aliphatic Index

    • 43.88
    • Half Life

      • Mammalian:1 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 11835
    • Absorbance 280nm

    • 246.56
    • Polar Residues

    • 17

DRAMP03620

DRAMP03620 chydropathy plot
    • Function

    • Has antibacterial activity (Potential).
    • PTM

    • Contains three disulfide bonds (By similarity).
  • ·Literature 1
    • Title

    • Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
    • Reference

    • Physiol Genomics. 2005 Sep 21;23(1):5-17.
    • Author

    • Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.
  • ·Literature 2
    • Title

    • Discovery of five conserved beta-defensin gene clusters using a computational search strategy.
    • Reference

    • Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2129-2133.
    • Author

    • Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr.
  • ·Literature 3
    • Title

    • The DNA sequence and comparative analysis of human chromosome 20.
    • Reference

    • Nature. 2001 Dec 20-27;414(6866):865-871.
    • Author

    • Deloukas P, Matthews LH, Ashurst J, Burton J, et al, Rogers J.