General Information
-
DRAMP ID
- DRAMP03627
-
Peptide Name
- Beta-defensin 132 (Defensin, beta 132; Beta-defensin 32, BD-32; Human, mammals, animals)
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Source
- Homo sapiens (Human)
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Family
- Belongs to the beta-defensin family
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Gene
- DEFB132
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Sequence
- GGSKCVSNTPGYCRTCCHWGETALFMCNASRKCCISYSFLPKPDLPQLIGNHWQSRRRNTQRKDKKQQTTVTS
-
Sequence Length
- 73
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Bridge
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03627.
Physicochemical Information
-
Formula
- C353H562N112O105S8
Absent Amino Acids
- ?
Common Amino Acids
- CSTKR
Mass
- 8311.51
PI
- 9.62
Basic Residues
- 14
Acidic Residues
- 3
Hydrophobic Residues
- 14
Net Charge
- +11
-
Boman Index
- -184.87
Hydrophobicity
- -0.834
Aliphatic Index
- 42.74
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 14355
Absorbance 280nm
- 199.38
Polar Residues
- 32
DRAMP03627
Comments Information
Function
- Has antibacterial activity (Potential).
PTM
- Contains three disulfide bonds (By similarity).
Literature Information
- ·Literature 1
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Title
- Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.
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Pubmed ID
- 12620395
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Reference
- Genomics. 2003 Feb;81(2):175-183.
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Author
- Rodriguez-Jimenez FJ, Krause A, Schulz S, Forssmann WG, Conejo-Garcia JR, Schreeb R, Motzkus D.